Endocrine Abstracts

Introduction: Neuroendocrine tumors (NET) arise from tissue mucosal cells known as enterochromaffin cells. The clinical behavior of NET has been recognized over the past 30 years and genome analysis are needed for further follow up. Here we conduct integrated genome analyses on data from chromosomal gene copy number and transcriptome sequencing as well as analysis of overal survival of patients diagnosed with NET.Material and methods: The study accrued 6...

Introduction: Neuroendocrine tumors (NETs) are rare tumours that develop in cells of the neuroendocrine system. They comprise a heterogeneous group of neoplasms that range from the benign and multi-focal to the highly malignant and metastatic. Here we conduct itegrated genome and immunohistochemistry analysis (IHC) of the Ataxia Telangiectasia Mutated Gene (ATM) as well as analysis of overal survival in patients diagnosed with NETs.Material and Methods: ...

Introduction: Pancreatic neuroendocrine tumors (PNETs) are rare malignant neoplasms which incidence is continually increasing. They are characterized by diverse biological behaviour and impact on the patients’ prognosis, ranging from clinicaly indolent to very aggressive. Oxytocin receptor (OXTR) is a member of the family of G-protein receptors and is present on the cell-surface of the gastrointestinal organs. Unfortunately, theimpact of OXTR signaling on the development...